TY  - BOOK
AU  - Frederic Veyrier
AU  - Mathieu Cellier
AB  - From simple inorganic catalysts to vital biological cofactors, divalent transition metals are instrumental to electron transfers, catalysis and signaling. Their natural ability to bind, exchange and react with organic molecules including oxygen requires from living cells to regulate uptake with metabolic activities, sensing and chaperoning, distributing and storing, or excreting excess to prevent detrimental biochemical reactions. Since transition metal deficiency and overload both limit cell growth it is no surprise that the immune system evolved a dual strategy, of metal starvation or intoxication, to thwart microbial invasions. Like environmental metal availability determined biological use it also shaped host-microbe metal economy: Fe and Mn, available early in evolution and still required rather ubiquitously, are generally withheld by host in response to infection; Zn and Cu, which became bioavailable later, essentially to eukaryotic cells may be bombarded toward invaders. Successful microbial pathogens have evolved elaborate counter-measures to cope with host metal defenses. This research topic aims to review and discuss metal currencies in host-microbe interactions focusing on new findings about micro-organism pathogenesis determinants in the face of host innate strategies to interfere with microbial physiology.
DO  - 10.3389/978-2-88919-497-1
ID  - OAPEN ID: 17685
KW  - exporter
KW  - regulation
KW  - Virulence
KW  - transporter
KW  - metal
KW  - host
KW  - pathogen
L1  - http://journal.frontiersin.org/researchtopic/1380/metal-economy-in-host-microbe-interactions
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/53244
PB  - Frontiers Media SA
PY  - 2015
SN  - 9782889194971
TI  - Metal economy in host-microbe interactionsnull
ER  - 
