TY  - BOOK
AU  - Richter, Sara N.
AB  - G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), human papilloma virus, swine pseudorabies virus, and other viruses’ genomes. New evidence shows the presence of G4s in parasitic protozoa, such as the causative agent of malaria. G4 binding proteins and mRNA G4s have been implicated in the regulation of microorganisms’ genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle and as therapeutic agents. Moreover, new techniques to study G4 folding and their interactions with proteins have been developed. This Special Issue will focus on G4s present in microorganisms, addressing all the above aspects.
DO  - 10.3390/books978-3-03921-244-6
ID  - OAPEN ID: 42481
KW  - bacteria
KW  - folding
KW  - co-translational refolding
KW  - RecQ helicase
KW  - regulatory element
KW  - conformational dynamics
KW  - G4Hunter
KW  - NDPK
KW  - fluorescence
KW  - pseudorabies virus
KW  - Epstein-Barr virus (EBV)
KW  - structure-activity relationship
KW  - PhenDC3
KW  - eukaryotic hosts
KW  - Herpesvirus
KW  - translation suppression
KW  - turn-on ligands
KW  - co-transcriptional folding
KW  - Herpesviridae
KW  - G-quadruplex
KW  - nucleoside diphosphate kinase
KW  - nucleic acids
KW  - nucleic acids conformation
KW  - bioinformatics
KW  - protein–DNA interaction
KW  - aptamers
KW  - deinococcus
KW  - Alphaherpesvirinae
KW  - EBNA1
KW  - G4
KW  - virus
KW  - human papillomaviruses
KW  - S. cerevisiae
KW  - genome stability
KW  - G-quadruplexes
KW  - metastable structure
KW  - genome evolution
KW  - pyridostatin
KW  - alphaherpesviruses
KW  - structure
KW  - protozoa
KW  - genome
KW  - G-quadruplex ligand
KW  - NMR
KW  - microbes
KW  - DNA
KW  - protein-mRNA interactions
KW  - G-quadruplex formation
KW  - immediate early promoters
L1  - https://mdpi.com/books/pdfview/book/1495
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/48248
PB  - MDPI - Multidisciplinary Digital Publishing Institute
PY  - 2019
SN  - 9783039212439
SN  - 9783039212446
TI  - G-quadruplex and Microorganismsnull
ER  - 
