TY - BOOK AU - Shiina, Takashi AU - Dijkstra, Johannes M. AU - Kulski, Jerzy K. AB - The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species. DO - 10.3390/books978-3-03928-073-5 ID - OAPEN ID: 44737 KW - HCP5 KW - n/a KW - camels KW - MHC KW - STK19 KW - major histocompatibility complex KW - human papillomavirus (HPV) KW - T-cell receptor KW - T1DGC KW - bottleneck KW - micro-mini-pigs KW - life history KW - computational analysis KW - hepatocellular carcinoma KW - phase KW - Bactrian camel KW - NSDK KW - melanoma KW - antigen KW - autoimmune disease KW - RD KW - selection KW - disease resistance KW - autoimmunity KW - ancestral haplotype KW - Ski complex KW - DXO KW - high-throughput sequencing KW - conservation genetics KW - SVA KW - lncRNA KW - ankylosing spondylitis KW - MHC genes KW - viral peptides KW - competing endogenous RNA (ceRNA) KW - astrogliosis KW - birds KW - long-fragment super haplotype KW - SNP KW - RLR KW - HLA polymorphism KW - 5??3? RNA decay KW - expression KW - 3??5? mRNA turnover KW - orthology KW - long-read sequencing KW - disease association KW - dromedary KW - polyomavirus KW - MHC-II-associated sperm-egg recognition KW - experimental medicine KW - single nucleotide polymorphism (SNP) KW - fish KW - SKIV2L KW - production trait KW - molecular dynamics simulation KW - Macaca fascicularis KW - human endogenous retrovirus (HERV) KW - concerted evolution KW - polymorphism KW - Old World camels KW - MHC polymorphism KW - protocol KW - nonclassical KW - gene duplication KW - microglial reaction KW - human leukocyte antigen-E KW - SKI2W KW - quantitative trait loci (QTL) studies KW - antiviral immunity KW - human immunodeficiency virus (HIV) KW - founder effect KW - giant panda KW - domain movements KW - BK virus KW - promoter-proximal transcriptional pause KW - type 1 diabetes (T1D) KW - RP1 KW - miR1236 KW - KIR KW - synaptic covering KW - swine leukocyte antigen KW - cynomolgus macaque KW - HLA KW - kidney transplantation KW - ?2m knockout mice KW - DOM3Z KW - interferon ? KW - ethnic populations in China KW - ecology KW - KIR–HLA pairs KW - exosomes KW - major histocompatibility complex (MHC) KW - MHC-I-based mother-fetus recognition KW - RNA quality control KW - autoimmune diseases KW - NELF-E KW - haplotype KW - genetic drift KW - evolution KW - nonhuman primate models KW - HLA-B27 KW - PNS/CNS interface KW - risk genes KW - pedigree KW - MHC-I- and MHC-II-dependent inter-individual recognition KW - regulation KW - crested ibis KW - reproductive performance KW - nephropathy KW - cancer KW - nuclear kinase KW - trichohepatoenteric syndrome L1 - https://mdpi.com/books/pdfview/book/2011 LA - English LK - https://directory.doabooks.org/handle/20.500.12854/52604 PB - MDPI - Multidisciplinary Digital Publishing Institute PY - 2020 SN - 9783039280728 SN - 9783039280735 TI - Major Histocompatibility Complex (MHC) in Health and Diseasenull ER -