TY  - BOOK
AU  - Laima Taraseviciene-Stewart
AU  - Adelheid Kratzer
AU  - Michael Borchers
AB  - Cigarette smoke exposure is the key initiator of chronic inflammation, alveolar destruction, and the loss of alveolar blood vessels that lead to the development of chronic obstructive pulmonary disease (COPD) which is comprised of emphysema and chronic bronchitis. Exposure to secondhand smoke (SHS) is the major risk factor for non-smokers to develop emphysema. While the first-hand smoke is directly inhaled by smokers, passive smoking occurs when non-smokers are involuntary exposed to environmental tobacco smoke also known as second hand smoke (SHS). SHS is a mixture of 2 forms of smoke that come from burning tobacco: side stream smoke (smoke that comes from the end of a lit cigarette, pipe, or cigar) and mainstream smoke (smoke that is exhaled by a smoker). These two types of smoke have basically the same composition, however in SHS many toxic components are more concentrated than in first-hand smoke, therefore more hazardous for people’s health. Several pathological events have been implicated in the development of SHS-induced COPD, but many aspects of this pathology remain poorly understood halting the development of new advanced treatments for this detrimental disease. In this respect we have welcomed leading investigators in the field to share their research findings and provide their thoughts regarding the mechanisms of the SHS exposure-induced immune responses and inflammatory mechanisms of lung destruction in SHS-induced COPD and related comorbidities.
DO  - 10.3389/978-2-88919-316-5
ID  - OAPEN ID: 18578
KW  - Autoantibodies
KW  - Cytokines
KW  - pulmonary hypertension
KW  - pulmonary injections
KW  - Inflammation
KW  - matrix degradation
KW  - Immune responses
KW  - Macrophages
KW  - Cell signaling
KW  - Monocytes and lymphocytes
KW  - second hand smoke
KW  - Heart Failure
KW  - Emphysema
L1  - http://journal.frontiersin.org/researchtopic/710/second-hand-smoke-and-copd-lessons-from-animal-studies
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/59075
PB  - Frontiers Media SA
PY  - 2015
SN  - 9782889193165
TI  - Second hand smoke and COPD: lessons from animal studiesnull
ER  - 
