TY  - BOOK
AU  - Nagy, Bálint
AB  - The deficits of mammography and the potential of noninvasive diagnostic testing using circulating miRNA profiles are presented in our first review article. Exosomes are important in the transfer of genetic information. The current knowledge on exosome-associated DNAs and on vesicle-associated DNAs and their role in pregnancy-related complications is presented in the next article. The major obstacle is the lack of a standardized technique for the isolation and measurement of exosomes. One review has summarized the latest results on cell-free nucleic acids in inflammatory bowel disease (IBD). Despite the extensive research, the etiology and exact pathogenesis are still unclear, although similarity to the cell-free ribonucleic acids (cfRNAs) observed in other autoimmune diseases seems to be relevant in IBD. Liquid biopsy is a useful tool for the differentiation of leiomyomas and sarcomas in the corpus uteri. One manuscript has collected the most important knowledge of mesenchymal uterine tumors and shows the benefits of noninvasive sampling. Microchimerism has also recently become a hot topic. It is discussed in the context of various forms of transplantation and transplantation-related advanced therapies, the available cell-free nucleic acid (cfNA) markers, and the detection platforms that have been introduced. Ovarian cancer is one of the leading serious malignancies among women, with a high incidence of mortality; the introduction of new noninvasive diagnostic markers could help in its early detection and treatment monitoring. Epigenetic regulation is very important during the development of diseases and drug resistance. Methylation changes are important signs during ovarian cancer development, and it seems that the CDH1 gene is a potential candidate for being a noninvasive biomarker in the diagnosis of ovarian cancer. Preeclampsia is a mysterious disease—despite intensive research, the exact details of its development are unknown. It seems that cell-free nucleic acids could serve as biomarkers for the early detection of this disease. Three research papers deal with the prenatal application of cfDNA. Copy number variants (CNVs) are important subjects for the study of human genome variations, as CNVs can contribute to population diversity and human genetic diseases. These are useful in NIPT as a source of population specific data. The reliability of NIPT depends on the accurate estimation of fetal fraction. Improvement in the success rate of in vitro fertilization (IVF) and embryo transfer (ET) is an important goal. The measurement of embryo-specific small noncoding RNAs in culture media could improve the efficiency of ET.
DO  - 10.3390/books978-3-03928-075-9
ID  - OAPEN ID: 43639
KW  - n/a
KW  - screening
KW  - single nucleotide polymorphism
KW  - predictive and preventive approach
KW  - PTEN
KW  - cell-free DNAs
KW  - fetal fraction
KW  - gestational hypertension
KW  - RASSF1
KW  - CDH1
KW  - RT-PCR
KW  - cfDNA
KW  - statistical models
KW  - hematopoietic stem cell transplantation
KW  - NanoString
KW  - solid organ transplantation
KW  - copy number variants
KW  - sarcomas
KW  - liquid biopsy
KW  - obesity
KW  - fetal DNA
KW  - neutrophil extracellular traps
KW  - mammography
KW  - non-invasive prenatal testing
KW  - ovarian cancer
KW  - circulating miRNA
KW  - pyrosequencing
KW  - growth retardation
KW  - preeclampsia
KW  - gestational diabetes mellitus
KW  - biomarker
KW  - inflammatory bowel disease
KW  - multi-level diagnostics
KW  - PAX1
KW  - population study
KW  - nuclease activity
KW  - NETosis
KW  - omics
KW  - piRNA
KW  - cell-free DNA
KW  - prediction
KW  - leiomyosarcomas
KW  - network analysis
KW  - NGS
KW  - statistical methods
KW  - circulating nucleic acids
KW  - deletion/insertion polymorphism
KW  - gender differences
KW  - leiomyomas
KW  - fetal growth restriction
KW  - blood plasma
KW  - exosomes
KW  - miRNA
KW  - pregnancy-related complications
KW  - NIPT
KW  - genetic marker
KW  - cell-free nucleic acids
KW  - extracellular vesicles
KW  - expression
KW  - next generation sequencing
KW  - breast cancer
KW  - individualized patient profile
KW  - circulating tumor cells
KW  - maternal serum screening
KW  - personalized medicine
KW  - embryo culture medium
KW  - C19MC microRNA
KW  - DNA
KW  - cell-free RNAs
KW  - z-score
KW  - fetal cells
KW  - microchimerism
KW  - aging
KW  - plasma
L1  - https://www.mdpi.com/books/pdfview/book/1974
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/42861
PB  - MDPI - Multidisciplinary Digital Publishing Institute
PY  - 2020
SN  - 9783039280742
SN  - 9783039280759
TI  - Cell-Free Nucleic Acidsnull
ER  - 
