TY  - BOOK
AU  - Mallis, Panagiotis
AB  - Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold while keeping the extracellular matrix (ECM) intact. Furthermore, biologic scaffolds have been investigated for their in vitro potential for whole organ development. Currently, clinical products composed of decellularized matrices, such as pericardium, urinary bladder, small intestine, heart valves, nerve conduits, trachea, and vessels, are being evaluated for use in human clinical trials. Tissue engineering strategies require the interaction of biologic scaffolds with cellular populations. Among them, stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. Under this scheme, stem cells can be isolated from patients, expanded under good manufacturing practices (GMPs), used for the repopulation of biologic scaffolds and, finally, returned to the patient. The interaction between scaffolds and stem cells is thought to be crucial for their infiltration, adhesion, and differentiation into specific cell types. In addition, biomedical devices such as bioreactors contribute to the uniform repopulation of scaffolds. Until now, remarkable efforts have been made by the scientific society in order to establish the proper repopulation conditions of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of “artificial” tissues similar to native ones, which is achieved by properly combining stem cells and biologic scaffolds and thus bringing them one step closer to personalized medicine. The original research articles and comprehensive reviews in this Special Issue deal with the use of stem cells and biologic scaffolds that utilize state-of-the-art tissue engineering and regenerative medicine approaches.
DO  - 10.3390/books978-3-03921-498-3
ID  - OAPEN ID: 42566
KW  - nerve conduit
KW  - tissue engineering
KW  - regenerative medicine
KW  - mixed lymphocyte reaction
KW  - histological images
KW  - future scaffold engineering
KW  - multiparameter
KW  - 3DPVS
KW  - MSCs
KW  - Wnt signaling
KW  - Mesenchymal Stromal Cells
KW  - factorial design
KW  - novel scaffold
KW  - Wharton’s Jelly tissue
KW  - stem cells
KW  - umbilical arteries
KW  - SDS
KW  - platelet rich plasma
KW  - TGF? signaling
KW  - traditional scaffold
KW  - pluripotency and commitment
KW  - tissue engineered construct
KW  - HLA-G
KW  - CHAPS
KW  - platelets
KW  - proteomic analysis
KW  - vibrating nature of universe.
KW  - VS55
KW  - cell culture
KW  - FGF signaling
KW  - evolution of scaffold
KW  - dynamicity and dimensionality
KW  - fibrin gel
KW  - scaffold classification
KW  - decellularization
KW  - vitrification
KW  - seven-folder logics
KW  - IIEF-5 questionnaire
KW  - TGF-?1
KW  - erectile dysfunction
KW  - human induced pluripotent stem cells
KW  - iPSCs
KW  - scaffolds
KW  - Barret’s esophagus
KW  - nerve regeneration
KW  - long term storage
KW  - laws of system evolution
KW  - scaffold categorization
KW  - platelet lysate
KW  - 3D scaffold
KW  - esophagus
KW  - language of relativity
KW  - cord blood units
L1  - https://mdpi.com/books/pdfview/book/1650
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/60016
PB  - MDPI - Multidisciplinary Digital Publishing Institute
PY  - 2019
SN  - 9783039214976
SN  - 9783039214983
TI  - Stem Cell and Biologic Scaffold Engineeringnull
ER  - 
