TY  - BOOK
AU  - Pulido, Rafael
AU  - Lang, Roland
AB  - Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.
DO  - 10.3390/books978-3-03921-689-5
ID  - OAPEN ID: 42678
KW  - hematopoietic cells
KW  - DEPArray
KW  - n/a
KW  - neuroblastoma
KW  - liver steatosis
KW  - MAPK phosphatase
KW  - DUSP-4
KW  - granule neurons
KW  - neuronal differentiation
KW  - DUSP10
KW  - cytokines
KW  - MAPKs
KW  - single cell analysis
KW  - macrophage
KW  - asthma
KW  - E. coli infection
KW  - MAPK
KW  - Cpp1
KW  - nucleotide receptors
KW  - atypical DUSP
KW  - RSV
KW  - Pmp1
KW  - cannabinoids
KW  - astrocytes
KW  - sepsis
KW  - influenza
KW  - signaling
KW  - triple-negative breast cancer (TNBC)
KW  - differentiation
KW  - HDAC6 (histone deacetylase isoform 6)
KW  - atypical dual-specificity phosphatases
KW  - microtubules
KW  - respiratory viruses
KW  - MK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein)
KW  - dual-specificity phosphatase
KW  - Msg5
KW  - TLR signaling
KW  - mitogen-activated protein kinase
KW  - fungal MKPs
KW  - macrophages
KW  - MAP Kinase Phosphatase-2
KW  - inflammation
KW  - Sdp1
KW  - circulating tumor cells (CTCs)
KW  - MAP kinases
KW  - MAP kinase phosphatases
KW  - P2X7
KW  - proliferation
KW  - BDNF
KW  - P2Y13
KW  - T cell
KW  - hypertriglyceridemia
KW  - integrated omics analysis
KW  - post-translational modification
KW  - rhinovirus
KW  - protein stability
KW  - ubiquitination
KW  - dual-specificity phosphatases
KW  - Mkp-1
KW  - cancer
KW  - brain metastasis
KW  - HER2
KW  - COPD
KW  - pseudophosphatase
L1  - https://mdpi.com/books/pdfview/book/1856
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/45547
PB  - MDPI - Multidisciplinary Digital Publishing Institute
PY  - 2019
SN  - 9783039216895
SN  - 9783039216888
TI  - Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Functionnull
ER  - 
