TY  - BOOK
AU  - Arnon Dias Jurberg
AU  - Paul J Brindley
AB  - Schistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic necrotic ulcerations in the intestinal mucosa, urogenital tract diseases, in addition to cardiopulmonary, renal and neurologic lesions due to egg accumulation in the liver, intestines, uro-genital tissues and other sites. Urogenital schistosomiasis is a risk factor for bladder cancer and increases the risk of transmission of HIV infection. Despite extensive effort to control this NTD over the years, deployment on a considerable scale of commercially available drugs in endemic populations has induced the emergence of resistant isolates and raised the need to identify new targets for alternative therapies. Because of the availability of genomes of the three major species of human schistosomiasis, and through advances in functional genomics and live imaging, studies on schistosomes have now come into focus as models to investigate adaptations to parasitism and developmental biology of trematodes and cestodes, and indeed flatworms and Lophotrochozoans, at large. This Research Topic aims at gathering state-of-art essays on schistosome genetics, genetics, pathobiology and immunobiology. It also aims to highlight advances in understanding of the host-parasite relationship, in paradigms that address this NTD, and to discuss new perspectives and advances in chemotherapy and immunoprophylaxis.
DO  - 10.3389/978-2-88919-556-5
ID  - OAPEN ID: 18165
KW  - Schistosomiasis
KW  - Schistosoma mansoni
KW  - S japonicum
KW  - neglected tropical diseases
KW  - infection induced cancer
KW  - Anthelmintic drugs
KW  - S haematobium
KW  - Blood fluke
KW  - Vaccines
KW  - Helminthiasis
L1  - http://journal.frontiersin.org/researchtopic/2094/gene-function-in-schistosomes-recent-advances-towards-a-cure
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/48349
PB  - Frontiers Media SA
PY  - 2015
SN  - 9782889195565
TI  - Gene function in schistosomes: recent advances towards a curenull
ER  - 
