TY  - BOOK
AU  - Dormond, Olivier
AB  - The mechanistic target of rapamycin (mTOR) is a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes, including protein, lipid, and nucleotide synthesis, as well as autophagy. Over the last two decades, major molecular advances have been made in mTOR signaling and have revealed the complexity of the events implicated in mTOR function and regulation. In parallel, the role of mTOR in diverse pathological conditions has also been identified, including in cancer, hamartoma, neurological, and metabolic diseases. Through a series of articles, this book focuses on the role played by mTOR in cellular processes, metabolism in particular, and highlights a panel of human diseases for which mTOR inhibition provides or might provide benefits. It also addresses future studies needed to further characterize the role of mTOR in selected disorders, which will help design novel therapeutic approaches. It is therefore intended for everyone who has an interest in mTOR biology and its application in human pathologies.
DO  - 10.3390/books978-3-03921-061-9
ID  - OAPEN ID: 33689
KW  - n/a
KW  - primary cilia
KW  - neurodegeneration
KW  - nutrient sensor
KW  - PI3K
KW  - transcriptomics
KW  - phosphorylation
KW  - metabolic reprogramming
KW  - autophagy
KW  - Alzheimer’s disease
KW  - rapalogs
KW  - liver
KW  - angiogenesis
KW  - mTOR complex
KW  - MBSCs
KW  - advanced biliary tract cancers
KW  - Medulloblastoma
KW  - epithelial to mesenchymal transition
KW  - AMPK
KW  - p70S6K
KW  - lipid metabolism
KW  - thyroid cancer
KW  - sodium iodide symporter (NIS)/SLC5A5
KW  - male fertility
KW  - anesthesia
KW  - illumina
KW  - mTOR inhibitor
KW  - miRNA
KW  - Hutchinson-Gilford progeria syndrome (HGPS)
KW  - eIFs
KW  - Emery-Dreifuss muscular dystrophy (EDMD)
KW  - glucose
KW  - AKT
KW  - oral cavity squamous cell carcinoma (OSCC)
KW  - glucose and lipid metabolism
KW  - cellular signaling
KW  - aging
KW  - tumor microenvironment
KW  - rapamycin
KW  - leukemia
KW  - chloral hydrate
KW  - rapalogues
KW  - schizophrenia
KW  - T-cell acute lymphoblastic leukemia
KW  - senescence
KW  - lamin A/C
KW  - neurotoxicity
KW  - neurodevelopment
KW  - inhibitor
KW  - methamphetamine
KW  - pulmonary fibrosis
KW  - mTOR
KW  - mTOR inhibitors
KW  - combination therapy
KW  - proteolysis
KW  - fluid shear stress
KW  - tumour cachexia
KW  - biomarkers
KW  - synapse
KW  - gluconeogenesis
KW  - mTOR signal pathway
KW  - Sertoli cells
KW  - immunosenescence
KW  - miRNome
KW  - protein aggregation
KW  - senolytics
KW  - metabolism
KW  - NGS
KW  - mTORC2
KW  - mTORC1
KW  - metabolic diseases
KW  - IonTorrent
KW  - apoptosis
KW  - dopamine receptor
KW  - nocodazole
KW  - microenvironment
KW  - everolimus
KW  - acute myeloid leukemia
KW  - immunotherapy
KW  - spermatogenesis
KW  - bone remodeling
KW  - signalling
KW  - targeted therapy
KW  - ageing
KW  - therapy
KW  - NVP-BEZ235
KW  - fructose
KW  - physical activity
KW  - laminopathies
KW  - MC3T3-E1 cells
KW  - cell signaling
KW  - microRNA
KW  - cancer
KW  - lipolysis
KW  - melatonin
KW  - Parkinson’s disease
L1  - https://mdpi.com/books/pdfview/book/1355
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/54029
PB  - MDPI - Multidisciplinary Digital Publishing Institute
PY  - 2019
SN  - 9783039210619
SN  - 9783039210602
TI  - mTOR in Human Diseasesnull
ER  - 
