TY - BOOK ED - Kahaly, George J. AB - This open access book presents the history, pharmacokinetics and pharmacodynamics of levothyroxine, discussing its role in the thyroid pathophysiology of patients of various ages and during pregnancy. It also describes the influence of levothyroxine on heart, bone and in cancer. When it was first synthesized in 1949, levothyroxine represented a significant advance in the treatment of hypothyroidism, providing a safe and effective treatment option for millions of hypothyroid patients around the globe. This synthetic form of thyroxine is now one of the most prescribed drugs in the world. Levothyroxine was first introduced by Merck KGaA,Darmstadt, Germany, in 1972, and since then the company has remained actively engaged in research on this mainstay of hypothyroidism treatment. This book is intended for healthcare professionals. DO - 10.1007/978-3-030-63277-9 ID - OAPEN ID: ONIX_20210315_9783030632779_18 ID - OAPEN ID: https://library.oapen.org/handle/20.500.12657/47292 KW - Endocrinology KW - Pharmacology/Toxicology KW - Pharmacology KW - Thyroid gland KW - Hypothyroidism KW - TSH KW - Thyroid disorders KW - Metabolism KW - Open Access L1 - https://library.oapen.org/bitstream/20.500.12657/47292/1/9783030632779.pdf LA - English LK - https://directory.doabooks.org/handle/20.500.12854/64050 PB - Springer Nature PY - 2021 SN - 9783030632779 TI - 70 Years of Levothyroxinenull ER -