TY  - BOOK
AU  - Aouizerate, Bruno
AU  - Haffen, Emmanuel
AB  - Major depression and obsessive–compulsive disorder (OCD) are now recognized among the most frequent psychiatric disorders, affecting 16–17% and 2–3% of the general population, respectively. They are commonly characterized by: i) a high level of psychiatric and somatic comorbidities; ii) a recurrence or chronic profile; and iii) a negative impact on daily functions, thereby leading to a profound impairment of quality of life. Despite significant advances in pharmacological and psychological therapies over the last decades, unsuccessful responses to standard treatment strategies are classically observed in approximately 20–30% of cases. Therefore, there is a significant need for improving the pathophysiological knowledge through a better identification of environmental, clinical, psychological, genetic, anatomical, and biological determinants, specifically implied in the development, the phenotypic expression, and the relapsing course and/or contributing to the therapeutic failure in major depression and OCD. We are convinced that this research approach is particularly relevant providing critical support for the promotion of innovative treatment alternatives potentially useful for the management of resistant forms of major depression and OCD.
DO  - 10.3390/books978-3-03921-091-6
ID  - OAPEN ID: 33715
KW  - n/a
KW  - i-health
KW  - olfaction
KW  - psychiatry
KW  - obsession
KW  - obsessive–compulsive disorder
KW  - transcranial direct current stimulation
KW  - ecological momentary assessment
KW  - Streptococcus pyogenes
KW  - cytokines
KW  - immunology
KW  - compulsion
KW  - cognition
KW  - nosography
KW  - pediatric autoimmune neuropsychological disorders associated with streptococcal infection (PANDAS)
KW  - symptoms networks
KW  - brain stimulation
KW  - neuromodulation
KW  - OCD
KW  - m-health
KW  - categorizations
KW  - ecological momentary intervention
KW  - fictional case study
KW  - pediatric acute-onset neuropsychiatric syndrome (PANS)
KW  - Toxoplasma gondii
KW  - tDCS
KW  - therapeutic tool
KW  - depression
KW  - markers
KW  - quality of life
KW  - Tourette syndrome
L1  - https://mdpi.com/books/pdfview/book/1385
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/54614
PB  - MDPI - Multidisciplinary Digital Publishing Institute
PY  - 2019
SN  - 9783039210909
SN  - 9783039210916
TI  - New Research in Obsessive-Compulsive Disorder and Major Depressionnull
ER  - 
