TY  - BOOK
AU  - Robert J. Harvey
AU  - Kirsten Harvey
AB  - The advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. In turn, these models may enable understanding of key disease processes and the identification of new targets for the medicines of the future. This e-book contains original research papers and reviews that highlight either the impact of next-generation sequencing in the understanding of neurological disorders, or utilise molecular, cellular, and whole-organism models to validate disease-causing or protective sequence variants.
DO  - 10.3389/978-2-88945-173-9
ID  - OAPEN ID: 23478
KW  - Stem Cells
KW  - glycine receptor
KW  - Amyotrophic Lateral Sclerosis
KW  - Parkinson's disease
KW  - PET imaging
KW  - LRRK2
KW  - Zebrafish
KW  - Inflammation
KW  - GABA-A receptor
KW  - NMDA receptors
KW  - Intellectual Disability
L1  - http://journal.frontiersin.org/researchtopic/4437/molecular-cellular-and-model-organism-approaches-for-understanding-the-basis-of-neurological-disease
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/53863
PB  - Frontiers Media SA
PY  - 2017
SN  - 9782889451739
TI  - Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Diseasenull
ER  - 
