TY  - BOOK
AU  - Williams, Gareth R.
AU  - Blagbrough, Ian S.
AB  - This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
DO  - 10.3390/books978-3-03897-913-5
ID  - OAPEN ID: 33725
KW  - tissue engineering
KW  - cyclodextrin
KW  - permeability
KW  - poly (vinylpyrrolidone-co-vinyl acetate)
KW  - crystalline
KW  - antibacterial
KW  - drug delivery
KW  - homogenization
KW  - capsaicin
KW  - combination therapy
KW  - high-shear mixing
KW  - cyclodextrin-inclusion complexes
KW  - amorphous
KW  - high-speed electrospinning
KW  - PMVE/MA
KW  - aqueous solubility enhancement
KW  - sieve analysis
KW  - Raman mapping
KW  - Eudragit
KW  - nanofibers
KW  - psoriasis
KW  - PCL
KW  - essential oils
KW  - parameters
KW  - antibiotics
KW  - xanthan gum
KW  - carvedilol
KW  - amorphous composite
KW  - coaxial electrospinning
KW  - insoluble drug
KW  - NIR-triggered drug release
KW  - fast dissolution
KW  - electrospinning
KW  - oral drug delivery
KW  - electrospun nanofibers
KW  - poly-cyclodextrin
KW  - TRPV1
KW  - gallic acid
KW  - solid dispersion
KW  - photothermal therapy
KW  - drug release
KW  - applications
L1  - https://mdpi.com/books/pdfview/book/1346
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/46161
PB  - MDPI - Multidisciplinary Digital Publishing Institute
PY  - 2019
SN  - 9783038979135
SN  - 9783038979128
TI  - Electrospun and Electrosprayed Formulations for Drug Deliverynull
ER  - 
