TY  - BOOK
AU  - David A. Rosenblueth
AB  - The complexity of living organisms surpasses our unaided habilities of analysis. Hence, computational and mathematical methods are necessary for increasing our understanding of biological systems. At the same time, there has been a phenomenal recent progress allowing the application of novel formal methods to new domains. This progress has spurred a conspicuous optimism in computational biology. This optimism, in turn, has promoted a rapid increase in collaboration between specialists of biology with specialists of computer science. Through sheer complexity, however, many important biological problems are at present intractable, and it is not clear whether we will ever be able to solve such problems. We are in the process of learning what kind of model and what kind of analysis and synthesis techniques to use for a particular problem. Some existing formalisms have been readily used in biological problems, others have been adapted to biological needs, and still others have been especially developed for biological systems. This Research Topic has examples of cases (1) employing existing methods, (2) adapting methods to biology, and (3) developing new methods. We can also see discrete and Boolean models, and the use of both simulators and model checkers. Synthesis is exemplified by manual and by machine-learning methods. We hope that the articles collected in this Research Topic will stimulate new research.
DO  - 10.3389/978-2-88945-042-8
ID  - OAPEN ID: 25551
KW  - model checking
KW  - Logic programing
KW  - Answer set programing
KW  - attractors of Boolean networks
KW  - synthesis of biochemical models
KW  - Gene Regulatory Networks
KW  - Boolean networks
KW  - biochemical networks
L1  - http://journal.frontiersin.org/researchtopic/2177/computational-methods-for-understanding-complexity-the-use-of-formal-methods-in-biology
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/43706
PB  - Frontiers Media SA
PY  - 2016
SN  - 9782889450428
TI  - Computational Methods for Understanding Complexity: The Use of Formal Methods in Biologynull
ER  - 
