TY  - BOOK
AU  - Szostak, Michal
AB  - The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N–C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.
DO  - 10.3390/books978-3-03921-204-0
ID  - OAPEN ID: 35900
KW  - N-heterocyclic carbene
KW  - non planar amide
KW  - ruthenium (Ru)
KW  - physical organic chemistry
KW  - gemcitabine prodrug
KW  - pyramidal amides
KW  - bridged sultams
KW  - catalysis
KW  - dipeptides
KW  - N-(1-naphthyl)acetamide
KW  - C-N ? bond cleavage
KW  - steric effects
KW  - peptide bond cleavage
KW  - transition-metal-free
KW  - palladium
KW  - N-heterocyclic carbenes (NHCs)
KW  - addition reaction
KW  - C–O activation
KW  - rhodium
KW  - metal complexes
KW  - carbanions
KW  - thioamidation
KW  - amide bond
KW  - intramolecular catalysis
KW  - antiviral activity
KW  - additivity principle
KW  - pre-catalysts
KW  - C–N bond cleavage
KW  - bridged lactams
KW  - C–H acidity
KW  - arynes
KW  - twisted amides
KW  - organic synthesis
KW  - amination
KW  - Suzuki-Miyaura
KW  - tert-butyl
KW  - cyclopentadienyl complexes
KW  - C-S formation
KW  - enzymes
KW  - DFT study
KW  - sulfonamide bond
KW  - N
KW  - HERON reaction
KW  - primaquine
KW  - entropy
KW  - amide activation
KW  - amidation
KW  - synthesis
KW  - amide hydrolysis
KW  - carbonylicity
KW  - amide bond activation
KW  - amide bond resonance
KW  - aminosulfonylation
KW  - molecular dynamics
KW  - model compound
KW  - in situ
KW  - amide
KW  - homogeneous catalysis
KW  - heterocycles
KW  - anomeric effect
KW  - multi-component coupling reaction
KW  - kinetic
KW  - excited state
KW  - C–H bond cleavage
KW  - palladium catalysis
KW  - amides
KW  - thiourea
KW  - formylation
KW  - alkynes
KW  - cis/trans isomerization
KW  - amide C–N bond activation
KW  - intein
KW  - C-H functionalization
KW  - succindiamide
KW  - amide bonds
KW  - crown ether
KW  - aminoacylation
KW  - directing groups
KW  - cytostatic activity
KW  - reaction thermodynamics
KW  - acyl transfer
KW  - transition metals
KW  - N-dimethylformamide
KW  - DMAc
KW  - acylative cross-coupling
KW  - C-H/C-N activation
KW  - nickel catalysis
KW  - antibacterial screening
KW  - sodium
KW  - aryl thioamides
KW  - Winkler-Dunitz parameters
KW  - catalyst
KW  - N-dimethylacetamide
KW  - base-catalyed hydrolysis
KW  - nitrogen heterocycles
KW  - cross-coupling
KW  - insertion
KW  - amidicity
KW  - nitro-aci tautomerism
KW  - activation
KW  - carbonylation
KW  - transamidation
KW  - amine
KW  - distortion
KW  - Pd-catalysis
KW  - rotational barrier energy
KW  - hypersensitivity
KW  - N–C activation
KW  - metabolic stability
KW  - [2+2+2] annulation
KW  - twisted amide
KW  - protease
KW  - cyanation
KW  - amide resonance
KW  - trialkylborane
KW  - catalysts
KW  - biofilm eradication
KW  - pharmacokinetics
KW  - pancreatic cancer cells
KW  - DMF
KW  - aryl esters
KW  - Michael acceptor
KW  - fumardiamide
KW  - water solvation
KW  - ester bond activation
KW  - cyclization
KW  - nuclear magnetic resonance
KW  - secondary amides
KW  - reaction mechanism
KW  - density functional theory
KW  - density-functional theory
KW  - amino acid transporters
L1  - https://mdpi.com/books/pdfview/book/1420
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/40763
PB  - MDPI - Multidisciplinary Digital Publishing Institute
PY  - 2019
SN  - 9783039212033
SN  - 9783039212040
TI  - Amide Bond Activationnull
ER  - 
