TY  - BOOK
AU  - Laurent Gautron
AU  - Alexander C Jackson
AU  - Chen Liu
AU  - Makoto Fukuda
AU  - Michael Lazarus
AB  - Neuroanatomists increasingly rely on techniques enabling them to manipulate genes in defined brain cell populations. In particular, engineered transgenes, which encode a variety of fluorescent reporter proteins can be inserted into the genome or delivered into desired brain regions using viral vectors, thereby allowing the labeling of molecularly-defined populations of neurons and/or glial cells. Transgenic technology can also be used to selectively delete genes in targeted neuronal populations or bi-directionally modulate their electrical excitability using optogenetic or chemogenetic techniques. One of the primary advantages of using transgenic reagents is to simplify the identification and tracing of targeted population of brain cells, which can be laborious using traditional techniques in neuroanatomy. In this research topic, we assembled up-to-date reviews and original articles that demonstrate the versatility and power of transgenic tools in advancing our knowledge of the nervous system, with a special emphasis on the application of transgenic technology to neuroanatomical questions.
DO  - 10.3389/978-2-88919-513-8
ID  - OAPEN ID: 17748
KW  - gene delivery
KW  - mouse models
KW  - tracing
KW  - transgenesis
KW  - morphology
KW  - adeno-associated virus
KW  - Fluorescent reporters
KW  - neuronal circuits
L1  - http://journal.frontiersin.org/researchtopic/1685/neuroanatomy-and-transgenic-technologies
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/54489
PB  - Frontiers Media SA
PY  - 2015
SN  - 9782889195138
TI  - Neuroanatomy and transgenic technologiesnull
ER  - 
